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        1. BPS Bioscience Inc.
          中級會員 | 第3年

          當(dāng)前位置:BPS Bioscience Inc.>>Inhibitors / Activators>> 27766-1NVP-BEP800

          NVP-BEP800

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          產(chǎn)品型號27766-1

          品       牌BPS Bioscience

          廠商性質(zhì)生產(chǎn)商

          所  在  地

          更新時(shí)間:2023-11-11 08:43:40瀏覽次數(shù):93次

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          ●Purchase●DescriptionNVP-BEP800isanovel,fullysynthetic,orallybioavailableinhibitorthatbindstotheNH(2)-terminalATP-bindingpocketofHsp90
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          Description

          NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Hsp90. NVP-BEP800 (also known as VER-82576) is a novel ATP-competitive HSP90β inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Heat shock protein 90 (Hsp90). NVP-BEP800 induced robust antitumor responses in tumor xenograft models, including regression in the BT-474 breast cancer model. NVP-BEP800 can radiosensitise tumour cell lines of different entities through destabilisation and depletion of several Hsp90 client proteins, thus causing the depletion of S phase and G2/M arrest, increased DNA damage and repair protraction and, to some extent, apoptosis.

          Synonyms
          VER-82576; 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide

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