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當(dāng)前位置:BPS Bioscience Inc.>>Inhibitors / Activators>> 27020Panobinostat
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產(chǎn)品型號27020
品 牌BPS Bioscience
廠商性質(zhì)生產(chǎn)商
所 在 地
更新時間:2023-11-11 08:39:21瀏覽次數(shù):82次
聯(lián)系我時,請告知來自 化工儀器網(wǎng)Panobinostat, also known as LBH-589, is a highly active, non-selective HDAC inhibitor. IC50’s against HDAC s 1-9 range between 3 – 61 nM except for a slightly higher IC50 value of 248 nM for HDAC 8. Panobinostat inhibits tumor cell proliferation and induces apoptosis in breast cancer and T cell lymphoma cells. In addition to its tumor-suppressive activities, panobinostat induces histone H3K9 and histone H4K8 acetylation and decreases the level of c-Myc expression.
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