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        1. BPS Bioscience Inc.
          中級(jí)會(huì)員 | 第2年

          13829799985

          當(dāng)前位置:BPS Bioscience Inc.>>技術(shù)服務(wù)>>檢測(cè)相關(guān)>> BPS Bioscience的KRAS篩選和檢測(cè)服務(wù)

          BPS Bioscience的KRAS篩選和檢測(cè)服務(wù)

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          更新時(shí)間:2023-12-19 23:23:59瀏覽次數(shù):228次

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            BPS Bioscience

          • 服務(wù)名稱:

            BPS Bioscience的KRAS篩選和檢測(cè)服務(wù)

          KRAS is an important protein in the RAS/MAPK signaling pathway that transmits signals from activated cell surface receptors leading to cell proliferation and survival. KRAS function is controlled by cycling through an inactive, GDP-bound state and an active, GTP-bound state. Activation of KRAS occurs when it binds to Guanine Nucleotide Exchange Factor (GEF) proteins, including SOS, which initiate the exchange of GDP for GTP. Active, GTP-bound KRAS can trigger activation of downstream signaling molecules including RAF, PI3K, and RAL. KRAS can self-inactivate by cleaving the terminal phosphate group on the GTP, converting it to GDP. This inactivation process is accelerated by GTPase-activating (GAP) proteins.

          KRAS has emerged as a target of significant clinical interest, due to mutations in the KRAS protein that promote the pathogenesis of 20-30% of human cancers. Testing a patient for the presence of specific KRAS mutants serves as a highly predictive marker for success rates to various types of lung and colon cancer therapies. The development of inhibitors against KRAS G12C, G12D, and G12V holds a promising future for oncology.

          圖片

          We offer wild-type and mutant KRAS screening and profiling services to identify specific inhibitors. Our team of experts, using our in-house developed biochemical assay kits, can provide:

          • Screening for activity across your compound library

          • Determination of IC50

          • Project guidance and questions answered in a timely manner

          • Delivery of detailed results promptly and on time

          If follow-up studies are required, we can provide the same active proteins as the ones used in our assays.

          Fluorogenic Nucleotide Exchange Assay

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          Fluorogenic Nucleotide Exchange Assays are homogeneous assays designed for the screening and profiling of KRAS antagonists/inhibitors. In this assay, KRAS is pre-loaded with fluorescent BODIPY-GDP. Adding GTP in the presence of EDTA displaces BODIPY-GDP. The fluorescence intensity decreases as the BODIPY-GDP is displaced by GTP. Several KRAS inhibitors lock KRAS in the (inactive) GDP-bound conformation and prevent GDP/GTP exchange. In this scenario, the fluorescence intensity increases with drug concentration as more BODIPY-GDP remains bound to KRAS.

          AlphaLISA® Coupled Nucleotide Exchange Assay

          圖片

          AlphaLISA® Coupled Nucleotide Exchange Assays are designed for the screening and profiling of KRAS antagonists/inhibitors by monitoring the binding of an effector protein such as the Ras binding domain of Raf1, (RBD-cRaf) to active KRAS (G12C, in this example). First, a sample containing GDP-loaded KRAS(G12C) is incubated with SOS1 and GTP for the nucleotide exchange. Next, RBD-cRAF is added and incubated for the effector-RAS binding. Then, acceptor and donor beads are added and incubated for detection followed by reading the Alpha-counts.

          Available Service Assays

          Nucleotide Exchange Assays

          KRAS Isoform B

          KRAS (G12C)

          KRAS (G12D)

          Coupled Nucleotide Exchange Assays

          KRAS (G12C)

          KRAS (G12D)

          KRAS (G12V)

          如果您需要了解更多關(guān)于我們的服務(wù)的信息,請(qǐng)聯(lián)系info。

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