PD-1/PD-L1 has become a research hotspot in tumor immunotherapy in recent years. Tumor cells recruit immunosuppressive cells and cytokines by overexpressing PD-1/PD-L1, reduce the Antigenicity of tumor cells, and tilt the balance of immune microenvironment from steady state to immunosuppression. This process is called immune editing.
Immune editing includes three processes: clearing, balancing, and escaping. Tumor cells ultimately evade the anti-tumor effects of the body's immune system through immune editing, forming clinically detectable tumors.
In recent years, research related to PD-1 antibodies has emerged, which may become a major anti-tumor tool.
Background of PD1 antibody (BXC-BE0146):
The InVivoMAb anti mouse PD-1 (CD279):
Research fields: cancer biology, immune checkpoint proteins, immunology;
Clone number: RMP1-14;
Antigen: PD-1;
Host source: rats;
Antibody subtype: IgG2a, κ;
Molecular weight: 150 kDa;
Recommended homotypic control: InVivoMAb anti mouse PD-1 (CD279) product number: BE0089;
Concentration: usually between 4 and 11 mg/ml depending on the batch;
Recommended dilution buffer: InVivoPure pH 7.0 dilution buffer, product number: IP0070;
艾美捷 PD1抗體(BXC-BE0146)背景:
該InVivoMAb 抗小鼠 PD-1 (CD279)(InVivoMAb anti-mouse PD-1 (CD279)):
研究領(lǐng)域:癌癥生物學(xué), 免疫檢查點(diǎn)蛋白, 免疫學(xué);
克隆號:RMP1-14;
抗原:PD-1;
宿主來源:大鼠;
抗體亞型:IgG2a, κ;
分子量:150 kDa;
推薦同型對照:InVivoMAb 抗小鼠 PD-1 (CD279)貨號為:BE0089;
濃度:因批次可能不同,通常在4-11 mg/ml之間;
推薦的稀釋緩沖液:InVivoPure pH 7.0 稀釋緩沖液,貨號:IP0070;
PD1抗體(BXC-BE0146)相關(guān)研究:
體內(nèi)單克隆抗體抗小鼠PD-1 (CD279) (克隆J43)
體內(nèi)單克隆抗體抗人類PD-1 (CD279) (克隆J116)
體內(nèi)單克隆抗體抗人類PD-1 (CD279) (克隆J110)
體內(nèi)單克隆抗體抗小鼠PD-1 (CD279) (克隆29F.1A12™)
體內(nèi)加上抗小鼠PD-1(CD279)(克隆J43)
體內(nèi)加上抗小鼠PD-1(CD279)(克隆29F.1A12™)
RecombiMAb 抗小鼠 PD-1 (CD279) (D265A) (克隆 RMP1-14-CP151)
RecombiMAb抗小鼠PD-1 (CD279) (克隆RMP1-14-CP157)
RecombiMAb抗小鼠PD-1 (CD279) (克隆RMP1-14-CP162)
體內(nèi)SIM抗人類PD-1(納武利尤單抗生物類似藥)
體內(nèi)加上抗小鼠PD-1(CD279)(克隆29F.1A12™)
體內(nèi)SIM抗人PD-1(帕博利珠單抗生物類似藥)(克隆帕博利珠單抗)
相關(guān)產(chǎn)品
免責(zé)聲明
- 凡本網(wǎng)注明“來源:化工儀器網(wǎng)”的所有作品,均為浙江興旺寶明通網(wǎng)絡(luò)有限公司-化工儀器網(wǎng)合法擁有版權(quán)或有權(quán)使用的作品,未經(jīng)本網(wǎng)授權(quán)不得轉(zhuǎn)載、摘編或利用其它方式使用上述作品。已經(jīng)本網(wǎng)授權(quán)使用作品的,應(yīng)在授權(quán)范圍內(nèi)使用,并注明“來源:化工儀器網(wǎng)”。違反上述聲明者,本網(wǎng)將追究其相關(guān)法律責(zé)任。
- 本網(wǎng)轉(zhuǎn)載并注明自其他來源(非化工儀器網(wǎng))的作品,目的在于傳遞更多信息,并不代表本網(wǎng)贊同其觀點(diǎn)和對其真實(shí)性負(fù)責(zé),不承擔(dān)此類作品侵權(quán)行為的直接責(zé)任及連帶責(zé)任。其他媒體、網(wǎng)站或個(gè)人從本網(wǎng)轉(zhuǎn)載時(shí),必須保留本網(wǎng)注明的作品第一來源,并自負(fù)版權(quán)等法律責(zé)任。
- 如涉及作品內(nèi)容、版權(quán)等問題,請?jiān)谧髌钒l(fā)表之日起一周內(nèi)與本網(wǎng)聯(lián)系,否則視為放棄相關(guān)權(quán)利。