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當前位置：BPS Bioscience Inc.>>Cell Signaling Pathway Cell Lines>> 79800-PSTAT3 Luciferase Reporter HEK293 Cell Line
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產(chǎn)品型號79800-P
品 牌BPS Bioscience
廠商性質(zhì)生產(chǎn)商
所 在 地
更新時間：2023-11-11 17:43:42瀏覽次數(shù)：160次
聯(lián)系我時，請告知來自 化工儀器網(wǎng)The STAT3 Luciferase Reporter HEK293 Cell Line is a HEK293 cell lines expressing firefly luciferase driven by STAT3 response elements located upstream of a minimal TATA promoter. After activation by cytokines or growth factors, endogenous STAT3 binds to the response elements, inducing transcription of the luciferase reporter.
This cell line has been validated to respond to human interleukin-6 (IL-6) and human IL-27. Functional validation experiments showed that IL-6-induced luciferase activity was decreased by the JAK inhibitor CP 690,550 and by an anti-IL-6 Receptor neutralizing antibody.
Figure 1: Illustration of the mechanism behind reporter expression in the STAT3 Luciferase Reporter HEK293 Cell Line.
Created with BioRender.com
This product has been cited 1 time.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
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