目錄:MedChemExpress LLC>>信號通路>> Rhosin hydrochloride | MedChemExpress
| CAS | 1281870-42-5 | 純度 | 99.93% |
|---|---|---|---|
| 分子量 | 394.86 | 分子式 | C??H??ClN?O |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-12646 | 應用領域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 1281870-42-5
MCE 國際站：Rhosin hydrochloride
產(chǎn)品活性：Rhosin hydrochloride 是一種有效的，特異性的 RhoA 亞家族 Rho GTPases 抑制劑，能特異性的結合 RhoA，抑制 RhoA-GEF 相互作用，Kd 值 ~ 0.4 uM，但不與 Cdc42 或 Rac1，GEF，LARG 相互作用。Rhosin hydrochloride 可誘導細胞凋亡。Rhosin hydrochloride 通過增強 D1 中棘神經(jīng)元的可塑性和降低過度興奮性來促進應激恢復。
研究領域：GPCR/G Protein | Apoptosis
作用靶點：Ras | Apoptosis
In Vitro: Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC50 ~30-50 μM, and causes decreased size and reduced number of mammospheres in MCF7 cells.
In Vivo: Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice.
?Rhosin (30 μM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice.
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