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LJH685

CAS No. : 1627710-50-2

MCE 國際站：LJH685

產(chǎn)品活性：LJH685 是一種有效的選擇性，ATP-競爭性的 RSK 抑制劑, 抑制 RSK1/2/3 生物活性, IC₅₀ 為 6、5、4 nM。

研究領(lǐng)域：MAPK/ERK Pathway  |  Apoptosis

作用靶點(diǎn)：Ribosomal S6 Kinase (RSK)  |  Apoptosis

In Vitro: LJH685 (0.01-100 μM; 72 hours) efficiently inhibits the growth of MDA-MB-231 and H358 cells in soft agar with EC₅₀s of 0.73 and 0.79 μM, respectively.
LJH685 (0.1-10 μM; 4 hours) efficiently reduces phosphorylation of YB1 at submicromolar concentrations and causes nearly complete inhibition at higher concentrations.

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