目錄:MedChemExpress LLC>>信號(hào)通路>> BMS-536924 | MedChemExpress
| 參考價(jià) | ￥ 1045 |
| 參考價(jià) | ￥ 1045 |
更新時(shí)間：2023-09-28 14:47:45瀏覽次數(shù)：112評(píng)價(jià)
聯(lián)系我們時(shí)請(qǐng)說明是化工儀器網(wǎng)上看到的信息，謝謝!
| CAS | 468740-43-4 | 純度 | 99.83% |
|---|---|---|---|
| 分子量 | 479.96 | 分子式 | C??H??ClN?O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號(hào) | HY-10262 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
CAS No. : 468740-43-4
MCE 國際站：BMS-536924
產(chǎn)品活性：BMS-536924 是一種具有口服活性，競(jìng)爭性和選擇性的胰島素樣生長因子受體 (IGF-1R) 激酶和胰島素受體 (IR) 抑制劑，IC50 分別為 100 nM 和 73 nM。BMS-536924 具有抗癌活性。
研究領(lǐng)域：Protein Tyrosine Kinase/RTK | Apoptosis
作用靶點(diǎn)：IGF-1R | Insulin Receptor | Apoptosis
In Vitro: BMS-536924 inhibits FAK and Lck with IC50s of 150 nM and 341 nM, respectively.
BMS-536924 (1 μM; every four days for 12 days) blocks pBabe-MCF10A and CD8-IGF-IR-MCF10A acinar proliferation.
BMS-536924 (0.01-1 μM; 24 hours) inhibits growth of CD8-IGF-IR-MCF10A cells and has an IC50 of 0.48 μM.
BMS-536924 (1 μM; for 4 days) induces apoptosis in CD8-IGF-IR-MCF10A acini.
BMS-536924 (0.1-1 μM; for 24 hours) decreases in S-phase cells and causes a G0/G1 block.
BMS-536924 (1 μM; 10 min, 1, 8, 24, 48 hours) inhibits IGF-IR signaling in pBabe-MCF10A cells and inhibits phosphorylation of CD8-IGF-IR. BMS-536924 time-dependently inhibits AKT phosphorylation.
In Vivo: BMS-536924 (100 mg/kg; gavage; daily; for 35 days) causes regression of xenografts in vivo and an average reduction of 76% tumor volume after 2 weeks.
相關(guān)產(chǎn)品：Bioactive Compound Library Plus | Apoptosis Compound Library | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Endocrinology Compound Library | Orally Active Compound Library | Anti-Pancreatic Cancer Compound Library | Angiogenesis-Related Compound Library | Anti-Prostate Cancer Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cytokine Inhibitors Library | Cell Death Library | SY-5609 | BRD4 Inhibitor-18 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | AAPK-25 | Dutasteride-13C6 | Oleic acid-13C | Anticancer agent 120 | Abacavir sulfate | Meloxicam-d3-1 | Thailanstatin D | SB-218078 | Toyocamycin | Sorafenib-d4 | Busulfan | PTC-028 | Dinaciclib | CR-1-31-B | 142I5 | Farudodstat | Ecteinascidin 770 | AT9283 | Staurosporine | SNS-032 | AZA1 | Antitumor agent-96 | Bleomycin A5 | Xevinapant | Mangiferin | Cambinol | hGGPPS-IN-1
熱門產(chǎn)品線：重組蛋白 | 化合物庫 | 天然產(chǎn)物 | 熒光染料 | PROTAC | 同位素標(biāo)記物 | 寡核苷酸 | 抗體 | 點(diǎn)擊化學(xué)
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)
會(huì)員.png)
3
化工儀器網(wǎng)