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Corin

CAS No. : 1808113-09-8

產(chǎn)品活性：Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a K_i(inact) of 110 nM for LSD1 and an IC₅₀ of 147 nM for HDAC1.

研究領(lǐng)域：Epigenetics  |  Cell Cycle/DNA Damage

作用靶點(diǎn)：Histone Demethylase  |  HDAC

In Vitro: Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC₅₀ 95 nM vs. MS-275 EC₅₀ 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM).

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