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BMS-986176

CAS No. : 1815613-42-3

產(chǎn)品活性：BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC₅₀ of 2 nM. BMS-986176 can be used for neurodegenerative diseases research.

研究領(lǐng)域：Neuronal Signaling

作用靶點(diǎn)：AAK1

In Vitro: Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis.

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