目錄:MedChemExpress LLC>>生化試劑>> Atuliflapon | MCE
CAS | 2041075-86-7 | 純度 | 98.14% |
---|---|---|---|
分子量 | 446.5 | 分子式 | C??H??N?O? |
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5 mg |
貨號 | HY-122908 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 2041075-86-7
產(chǎn)品活性:Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5?Lipoxygenase activating protein), with an IC50 of 2 nM. Atuliflapon is used in the study for coronary artery disease.
研究領(lǐng)域:Immunology/Inflammation
作用靶點:FLAP
In Vitro: Atuliflapon demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h.
Atuliflapon exhibits an IC50 of 39 nM for LTB4.
In Vivo: Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively.
Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood.
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