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KR-33493

CAS No. : 1021497-97-1

產(chǎn)品活性：KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).

研究領(lǐng)域：Apoptosis

作用靶點：TNF Receptor

In Vivo: Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUC_last is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics.

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