MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

LF3

CAS No. : 664969-54-4

產品活性：LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC₅₀ of 1.65 μM.

研究領域：Stem Cell/Wnt

作用靶點：β-catenin

In Vitro: LF3 inhibits Wnt/β-catenin signals in cells with exogenous reporters and in colon cancer cells with endogenously high Wnt activity. LF3 also suppresses features of cancer cells related to Wnt signaling, including high cell motility, cell-cycle progression, and the overexpression of Wnt target genes. However, LF3 does not cause cell death or interfere with cadherin-mediated cell-cell adhesion. Remarkably, the self-renewal capacity of cancer stem cells is blocked by LF3 in concentration-dependent manners.

In Vivo: LF3 reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer. Tumor growth is significantly reduced when mice with GFP^high cells are treated with LF3 at 50 mg/kg. LF3 treatment does not disturb the normal histology of the gut of mice.

相關產品：Bioactive Compound Library Plus  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Peptidomimetic Library  |  Anti-Aging Compound Library  |  Cytoskeleton Compound Library  |  Neuroprotective Compound Library  |  Anti-Breast Cancer Compound Library  |  Transcription Factor-Targeted Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Protein-protein Interaction Inhibitor Library  |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Osteogenesis Compound Library  |  Cancer Stem Cells Compound Library  |  Antihypertensive Compound Library  |  Membrane Protein-targeted Compound Library  |  CDK8-IN-11  |  FzM1  |  Wnt/β-catenin agonist 3 hydrochloride  |  Pamidronic acid  |  NRX-252114  |  (E)-Ferulic acid  |  UU-T01  |  L-Quebrachitol  |  HLY78  |  Wnt/β-catenin agonist 2  |  Cardiogenol C hydrochloride  |  Laduviglusib (GMP)  |  FzM1.8  |  iCRT-5  |  NRX-252262  |  NLS-StAx-h TFA  |  UU-T02  |  Dinactin  |  Triptonide  |  Astragaloside I  |  CWP232228  |  β-catenin-IN-2  |  SKL2001  |  Chrysomycin A  |  Nefopam-d₃  |  Cardamonin  |  DK419  |  MSAB

熱門產品線：重組蛋白  |  化合物庫  |  天然產物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種全球僅有化合物庫，我們致力于為全球科研客戶提供前沿的高品質小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領；
•   產品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產品，廣泛應用于新藥研發(fā)、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業(yè)技術服務；
•   設有專業(yè)的實驗中心和嚴格的質控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
•   產品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團隊跟蹤最新的制藥及生命科學研究進展，為您提供全球新的活性化合物；
•   與世界各大制藥公司及著名科研機構建立了長期的合作。