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PF-04979064

CAS No. : 1220699-06-8

產(chǎn)品活性：PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with K_is of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.

研究領(lǐng)域：PI3K/Akt/mTOR

作用靶點(diǎn)：PI3K  |  mTOR

In Vitro: PF-04979064 is tested against human class I PI3K isoforms PI3Kα, PI3Kγ, and PI3Kδ, with PI3Kα K_i of 0.13 nM, PI3Kγ K_i of 0.111 nM, and PI3Kδ K_i of 0.122 nM.

In Vivo: PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T_1/2=1.85 h, and F%=61%.

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