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ALM301

CAS No. : 1313439-71-2

產(chǎn)品活性：ALM301 is an orally active highly specific AKT inhibitor with IC₅₀ values of 0.13 µM, 0.09 µM and 2.75 µM for AKT1, AKT2 and AKT3, respectively. ALM301 inhibits AKT phosphorylation and modulates downstream signalling in vitro. ALM301 can inhibit cancer cell proliferation and tumor growth.

研究領(lǐng)域：PI3K/Akt/mTOR

作用靶點(diǎn)：Akt

In Vitro: ALM301 (0.001-10 µM; 72 h) inhibits the proliferation of cancer cells, and PI3KCA-mutant MCF-7 cells is the most sensitive; increases sub-G0 population in a dose-dependent manner.
ALM301 (1 µM; 1 h) inhibits AKT phosphorylation in MCF-7 and sustains up to 48 h, with an EC₅₀ value of 0.47 µM.

In Vivo: ALM301 (10, 30 and 100 mg/kg; p.o.; single dosage) inhibits pAKT^S473 in tumors and suppresses tumor growth.
ALM301 (3 or 10 mg/kg; p.o.; q.d. for 49 days) shows better tumor inhibition ability when combined with Tamoxifen (HY-13757A).

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