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5Z-7-Oxozeaenol

CAS No. : 253863-19-3

產(chǎn)品活性：5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC₅₀s of 8 nM and 52 nM, respectively.

研究領(lǐng)域：MAPK/ERK Pathway  |  Protein Tyrosine Kinase/RTK  |  Anti-infection

作用靶點(diǎn)：MAP3K  |  VEGFR  |  Antibiotic

結(jié)構(gòu)分類：酚類  |  單酚類  |  其他類  |  結(jié)構(gòu)分類

In Vitro: 5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC₅₀, 8.1 nM), less active on MEK1 (IC₅₀, 411 nM). 5Z-7-Oxozeaenol prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. 5Z-7-Oxozeaenol is also an inhibitor of VEGF-R2, with an IC₅₀ of 52 nM. 5Z-7-Oxozeaenol has inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE and SRC, with IC₅₀s of 110, 170, 340, 6300 and 6600 nM, respectively. 5Z-7-Oxozeaenol inhibits JNK/p38 paythway, but it is not a direct inhibitor and is signal specific. 5Z-7-Oxozeaenol suppresses the PMA-induced AP-1 activity almost to the basal level in the KT cells, but has no effects on IL-1-induced NF-kB activity in the KK cells.

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