目錄:MedChemExpress LLC>>生化試劑>> Talquetamab | MCE
CAS | 2226212-40-2 | 供貨周期 | 現(xiàn)貨 |
---|---|---|---|
規(guī)格 | 5 mg | 貨號 | HY-P99394 |
應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 2226212-40-2
產(chǎn)品活性:Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity.
研究領(lǐng)域:Immunology/Inflammation
作用靶點:CD3
In Vitro: Talquetamab (0.00128-4.0 μg/mL, 48 h) effectively induces multiple myeloma cell lysis and leads to a significant increase in the proportion of activated CD4+ and CD8+ T cells, as well as to a dose-dependent increase in the levels of granzyme B and inflammatory cytokines such as IL-6, IL-8 and TNF-α.
In Vivo: Talquetamab (JNJ-64407564) (0.1-50 µg, s.c. or i.v.) has significant antitumor activity in H929 and MM mouse models.
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