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Hirudin

CAS No. : 8001-27-2

產(chǎn)品活性：Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others.

研究領(lǐng)域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶點：Thrombin  |  Apoptosis

In Vitro: Hirudin inhibits the activity of thrombin, deprives the ability of thrombin to cleave fibrinogen, prevents the formation of fibrin and the cross-linking polymerization process of fibrin monomer in internal and external coagulation pathway.
Hirudin reduces cell apoptosis of human microvascular endothelial cells (HMVECs) and suppresses the expression of p-JAK2 via antagonizing thrombin.
Hirudin inhibits VEGF-Notch pathway and cell proliferation of HMVECs at high doses.
Hirudin (3-10 mg/mL) reverses the abnormal proliferation and fibrosis in HK-2 cells caused by TGF-β1.
Hirudin depresses the myocardial fibroblasts induced by angiotensin II by dose-dependently inhibits oxidative stress, regulates fibrosis-related factors, and represses the ERK1/2 pathway.

In Vivo: Hirudin increases the viability of rat random skin flap and reduces inflammatory responses.
Hirudin promotes the wound healing in SD rats after laser surgery.
Hirudin (10 and 15 mg/kg; i.g. once daily for 21 days) improves renal interstitial fibrosis to reduce renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice.

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