目錄:愛(ài)必信(上海)生物科技有限公司>>細(xì)胞生物學(xué)>>重組蛋白>> abs02003Recombinant human CTLA4(10ug)
參考價(jià) | ¥ 662 |
訂貨量 | ≥1件 |
¥662 |
≥1件 |
更新時(shí)間:2024-07-07 17:15:09瀏覽次數(shù):1408評(píng)價(jià)
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CAS | - | 純度 | - |
---|---|---|---|
分子量 | - | 分子式 | - |
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10ug;100ug |
貨號(hào) | abs02003 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
主要用途 | - |
描述:
Recombinant human CTLA4 protein aa 1-161 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant CTLA4 is 15.6 kDa. Purified CTLA4 protein is below the position of 26 kDa on SDS-PAGE gel under reduced condition.
CTLA4 protein is purified by proprietary chromatographic techniques.
Entrez Gene summary for CTLA4:
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
UniProtKB/Swiss-Prot: P16410 (CTLA4_HUMAN)
Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
別名:
Cytotoxic T-lymphocyte 4蛋白;Cytotoxic T-lymphocyte protein 4 / CTLA4
來(lái)源:
Mammalian cells
形態(tài):
Protein is supplied in 20 mM Tris,150 mM NaCl, 10% Glycerol, pH 7.5
儲(chǔ)存/保存方法:
Clear solution, frozen.Store at -70°C. At first use, aliquot and store at -70°C to avoid multiple freeze-thaws.
Accession:
NP_005205.2
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