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          目錄:愛(ài)必信(上海)生物科技有限公司>>細(xì)胞生物學(xué)>>重組蛋白>> abs02003Recombinant human CTLA4(10ug)

          Recombinant human CTLA4(10ug)
          • Recombinant human CTLA4(10ug)
          參考價(jià) 662
          訂貨量 ≥1
          具體成交價(jià)以合同協(xié)議為準(zhǔn)
          662
          ≥1
          具體成交價(jià)以合同協(xié)議為準(zhǔn)
          • 品牌 absin
          • 型號(hào) abs02003
          • 廠商性質(zhì) 生產(chǎn)商
          • 所在地 上海市
          屬性

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          更新時(shí)間:2024-07-07 17:15:09瀏覽次數(shù):1408評(píng)價(jià)

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          CAS - 純度 -
          分子量 - 分子式 -
          供貨周期 現(xiàn)貨 規(guī)格 10ug;100ug
          貨號(hào) abs02003 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
          主要用途 -
          Recombinant human CTLA4 protein aa 1-161 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant CTLA4 is 15.6 kDa.

          描述:

          Recombinant human CTLA4 protein aa 1-161 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant CTLA4 is 15.6 kDa. Purified CTLA4 protein is below the position of 26 kDa on SDS-PAGE gel under reduced condition.
          CTLA4 protein is purified by proprietary chromatographic techniques. 


          Entrez Gene summary for CTLA4:

          This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.


          UniProtKB/Swiss-Prot: P16410 (CTLA4_HUMAN)

          Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.


          別名:

          Cytotoxic T-lymphocyte 4蛋白;Cytotoxic T-lymphocyte protein 4 / CTLA4


          來(lái)源:

          Mammalian cells


          形態(tài):

          Protein is supplied in 20 mM Tris,150 mM NaCl, 10% Glycerol, pH 7.5


          儲(chǔ)存/保存方法:

          Clear solution, frozen.Store at -70°C. At first use, aliquot and store at -70°C to avoid multiple freeze-thaws.


          Accession:

          NP_005205.2

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