鳥苷酸轉(zhuǎn)換因子VAV1抗體

英文名稱 VAV1
中文名稱 鳥苷酸轉(zhuǎn)換因子VAV1抗體
別    名 Oncogene vav; p95Vav; Protooncogene vav; Proto-oncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; Vav proto-oncogene; VAV_HUMAN; VAV1.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 98kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human VAV1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

Function:
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.xy-3660R    srGAP3精神障礙相關(guān)GAP蛋白抗體
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xy-2299R    phospho-STMN2 (Ser50)磷酸化神經(jīng)生長相關(guān)蛋白SCG10抗體
xy-7729R    SMC5染色體結(jié)構(gòu)維持蛋白5抗體
xy-7730R    SMC6染色體結(jié)構(gòu)維持蛋白6抗體
xy-7727R    SMC2染色體結(jié)構(gòu)維持蛋白2抗體
xy-7725R    SA2粘結(jié)蛋白SA2抗體
xy-7728R    SMC4染色體結(jié)構(gòu)維持蛋白4抗體
xy-7724R    Nuclear protein stromal antigen 1粘結(jié)蛋白SA1抗體
xy-7716R    SPC25紡錘體極點(diǎn)構(gòu)成蛋白25抗體
xy-12348R    5T4滋養(yǎng)層細(xì)胞糖蛋白5T4抗體
xy-1657R    phospho-STAT1 (Tyr701)磷酸化信號(hào)轉(zhuǎn)導(dǎo)與轉(zhuǎn)錄激活因子1抗體
xy-1658R    phospho-STAT3 (Tyr705)磷酸化信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子3抗體
xy-1791R    phospho-STAT6 (Tyr641)磷酸化信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6抗體
xy-3525R    SIGLEC14唾液酸結(jié)合性免疫球蛋白樣凝集素14抗體
xy-0089R    Secretin receptor分泌素受體抗體
xy-1127R    beta Sarcoglycan肌聚多糖-β抗體
xy-3433R    Phospho-Syk (Tyr323)磷酸化非受體型酪氨酸蛋白激酶抗體
xy-3434R    Phospho-Syk (Tyr525 + Tyr526)磷酸化非受體型酪氨酸蛋白激酶抗體
xy-0645R    Rat secretory IgA分泌型免疫球蛋白A抗體
xy-1096R    SKP2細(xì)胞S期激酶相關(guān)蛋白2抗體
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xy-0495R    Selenoprotein W硒蛋白W抗體
xy-0545R    SCF干細(xì)胞生長因子抗體
xy-0783R    SDF1 beta基質(zhì)細(xì)胞衍生因子－1抗體
xy-1121R    Sema3A臂板蛋白3A抗體