8-羥基脫氧鳥(niǎo)苷抗體

英文名稱 8-OHdG
中文名稱 8-羥基脫氧鳥(niǎo)苷抗體
別    名 8 Hydroxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine; 8 hydroxy 2’ deoxyguanosine; 8 hydroxyguanine; 8 hydroxyguanosine; 8 OHG; 8-OHG; 8OG; 8OHdG; 8OHG; 8 Oxoguanine; 8 hydroxyguanine; 8 Oxo 7,8 dihydroguanine; 8 oxo Gua; 8 oxoG.
    
說(shuō) 明 書(shū) 0.1ml  0.2ml  
產(chǎn)品類型 藥物與化合物抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) 8-OHdG
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 0.283kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated to 8-OHdG
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.

Function:
Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1.

Subcellular Location:xy-5698R    phospho-RAC1(Ser71)磷酸化細(xì)胞遷移誘導(dǎo)因子5抗體
xy-5692R    Phospho-RelB(Ser573)磷酸化核轉(zhuǎn)錄因子NFKB-RelB蛋白抗體
xy-5695R    phospho-RPH3AL(Ser232)磷酸化Ras相關(guān)GTP結(jié)合蛋白抗體
xy-4185R    RelB轉(zhuǎn)錄因子RelB蛋白抗體
xy-4182R    RPA32復(fù)制因子A蛋白2
xy-5693R    phospho-RPA2(Thr21)磷酸化復(fù)制因子A蛋白2抗體
xy-4183R    RPH3ALRas相關(guān)GTP結(jié)合蛋白抗體
xy-5690R    phospho-Rab24(Ser95)磷酸化ras基因相關(guān)蛋白R(shí)ab24抗體
xy-5691R    phospho-Rab24(Tyr17)磷酸化ras基因相關(guān)蛋白R(shí)ab24抗體
xy-5687R    phospho-RGS19(Ser24)磷酸化G蛋白信號(hào)轉(zhuǎn)導(dǎo)調(diào)節(jié)因子19抗體
xy-5688R    phospho-RGS19(Ser151)磷酸化G蛋白信號(hào)轉(zhuǎn)導(dǎo)調(diào)節(jié)因子19抗體
xy-5682R    phospho-RPS6KA1(Ser352)磷酸化絲氨酸/蘇氨酸激酶p90RSK蛋白抗體
xy-5684R    phospho-RAD51(Tyr315)磷酸化Rad51抗體
xy-5685R    phospho-RUNX2(Ser451)磷酸化成骨特異性轉(zhuǎn)錄因子抗體
xy-5689R    phospho-RGS19(Tyr143)磷酸化G蛋白信號(hào)轉(zhuǎn)導(dǎo)調(diào)節(jié)因子19抗體
xy-3867R    RGS19G蛋白信號(hào)轉(zhuǎn)導(dǎo)調(diào)節(jié)因子19抗體
xy-6142R    RING1環(huán)指蛋白1抗體
xy-4132R    MST1R原癌基因c-Met相關(guān)酪氨酸激酶抗體
xy-5489R    phospho-Ron(Ser1349)磷酸化原癌基因c-Met相關(guān)酪氨酸激酶抗體
xy-5795R    Robo4腫瘤血管內(nèi)皮調(diào)節(jié)蛋白R(shí)obo4抗體
xy-5794R    Robo軸突導(dǎo)向受體抗體
xy-1560R    Reelin絡(luò)絲蛋白抗體
xy-13677R    RUSC1RUSC1抗體
xy-13678R    RUSC2RUSC2抗體
xy-13698R    RAGEF2RAGEF2蛋白抗體
xy-12389R    RAB23G蛋白偶聯(lián)受體RAB23抗體
xy-15502R    RGS14 G蛋白信號(hào)調(diào)節(jié)因子14抗體
xy-7343R    RANK核轉(zhuǎn)錄因子NF-κB受體/核因子kB受體活化因子抗體
xy-3024R    phospho-RUNX1 (Ser266)磷酸化急性髓細(xì)胞白血病1蛋白抗體
xy-9362R    phospho-Proteasome 20S beta 7(Ser214)磷酸化蛋白酶體PSMβ7抗體
xy-3808R    Radixin根蛋白抗體
xy-6887R    Rb2 p130視網(wǎng)膜母細(xì)胞瘤樣蛋白2抗體
xy-2802R    RXR gamma維甲酸受體G抗體
xy-13280R    RASA1Rho GTP酶激活蛋白1/血管畸形骨肥大綜合征相關(guān)蛋白抗體