卷曲螺旋結(jié)構(gòu)域蛋白99抗體

英文名稱 Spindly
中文名稱 卷曲螺旋結(jié)構(gòu)域蛋白99抗體
別    名 Rrhabdomyosarcoma antigen protein MU RMS 40.4A; Arsenite related gene 1 protein; Arsenite-related gene 1 protein; CCDC 99; Ccdc99; Coiled coil domain containing 99; Coiled-coil domain-containing protein 99; hSpindly; Protein Spindly; rhabdomyosarcoma antigen MU RMS 40.4A; Rhabdomyosarcoma antigen MU-RMS-40.4A; SPDLY_HUMAN; Spindly.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Protein Spindly
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The five integral families of plant hormones consists of auxins, cytokinins, giberellins (GAs), abscisic acid (ABA), and ethylene. Giberellins, which consist of over fifty family members, mediate shoot growth. In Arabidopsis, SPINDLY (SPY) negatively regulates GA signal transduction. ERA1 (enhanced response to absisic acid), which is identical to WIGGUM, controls floral and shoot apical meristem size and floral organ number in response to ABA. Ethylene is perceived by a family of five receptors, one of which is ETR1, whereas CTR1 is a negative regulator of the ethylene signal transduction pathway . Ethylene is also produced endogenously in Arabidopsis via a biosynthetic pathway, which is catalyzed by ACC synthase and ACC oxidase.

Function:
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.xy-11944R    RILPL2Rab溶酶體相互作用蛋白樣2抗體
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