突觸相關(guān)蛋白102抗體

英文名稱 MPP3/SAP102
中文名稱 突觸相關(guān)蛋白102抗體
別    名 Discs large Drosophila homolog 3; Discs large homolog 3 neuroendocrine dlg Drosophila; Discs large homolog 3; Discs large homolog 3 Drosophila; Discs, large homolog 3 (Drosophila); Disks large homolog 3; DLG 3; DLG3; DLG3_HUMAN; MPP3; MPP-3; KIAA1232; mKIAA1232; MRX 90; MRX; MRX90; NE Dlg; NEDLG; Neuroendocrine dlg; Neuroendocrine-DLG; OTTHUMP00000023475; OTTHUMP00000023476; OTTHUMP00000023477; SAP 102; SAP-102; SAP102; Synapse associated protein 102; Synapse-associated protein 102; XLMR; bA291O7.3; bA291O7.3 discs large Drosophila homolog 3 neuroendocrine dlg.
  
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAP102
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生 產(chǎn) 商 BIOSS
PubMed PubMed
產(chǎn)品介紹 background:
MPP3, also known as Discs large homolog 3 (DLG3), is a 585 amino acid protein belonging to the MAGUK family. Proteins in the MAGUK family, including CASK, ZO-1, ZO-2, p55 and MPP2, are known to regulate cell proliferation, intracellular junctions and signaling pathways by interacting with the cytoskeleton. MPP3 contains one guanylate kinase-like domain, one PDZ domain, two L27 domains and one SH3 domain. Via the PDZ domain, MMP3 interacts with the C-terminus of TSLC1. MMP3 has also been found to interact with SR-2A and SR-4.

Function:
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

Subunit:
Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4.

DISEASE:
Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300189]. Mental retardation is characterized by significantly sub-average general inlectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.

Similarity:
Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 4356 Human

Omim: 601114 Human

SwissProt: Q13368 Human

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xy-3191R    Phospho-IKB beta (Ser23) 磷酸化KB抑制蛋白β抗體
xy-5509R    Phospho-NFKB1 (Ser903)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-3812R    NEDD8泛素樣蛋白NEDD8抗體
xy-8171R    NFIC核因子1C型抗體
xy-5527R    phospho-NPTX1(Tyr344)磷酸化神經(jīng)細(xì)胞正五聚體1抗體
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xy-8535R    phospho-NFATC4 (Ser168 + Ser170)磷酸化T細(xì)胞激活核轉(zhuǎn)錄因子4抗體
xy-12867R    NR1H4膽汁酸受體抗體
xy-12400R    NKAPNFKB激活蛋白抗體
xy-12401R    NLE1NLE1蛋白抗體
xy-13072R    Phospho-eNOS (Ser116)磷酸化一氧化氮合成酶3（內(nèi)皮型）抗體
xy-13073R    Phospho-eNOS (Ser615)磷酸化一氧化氮合成酶3（內(nèi)皮型）抗體
xy-13074R    Phospho-eNOS (Ser632)磷酸化一氧化氮合成酶3（內(nèi)皮型）抗體
xy-10376R    Orexin A增食欲素A/欲激素A抗體
xy-15509R    Orexin A增食欲素A/欲激素A抗體
xy-7344R    OAS32'-5'-寡腺苷酸合成酶3抗體
xy-12377R    OSR2牙齒發(fā)育相關(guān)蛋白Osr2抗體
xy-3816R    Oct-4B(OCT4B-190)NT胚胎干細(xì)胞關(guān)鍵蛋白190抗體(N端)
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xy-6236R    OTUB泛素特異性蛋白酶Otubain2抗體
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