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小鼠Wnt-3a蛋白（25ug,W3A-M-025 ）基本信息：

Description: Wnt-3a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Expression of Wnt-3a occurs primarily along the dorsal midline across overlapping regions of the Central Nervous System （CNS）. Wnt-3a signaling is essential for various morphogenetic events including embryonic patterning, cell determination, cell proliferation, CNS development, and cytoskeletal formation. like other members of this family, Wnt-3a contains a highly conserved lipid modified cysteine rich domain that is essential for cell signaling. During a biochemical process called the canonical Wnt pathway; Wnt family members bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimay leading to the disruption of β-Catenin degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors to promote gene expression. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes and has shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Recombinant murine Wnt-3a is a monomeric glycoprotein containing 328 amino acid residues. Due to glycosylation, the murine Wnt-3a migrates at an apparent molecular weight of approximay 38.0-41.0 kDa by SDS-PAGE analysis under non-reducing conditions.

Source: cell culture

Molecular Weight: 38-41 kDa Purity: > 75% by SDS-PAGE and HPLC analysis Endotoxin level/內(nèi)毒素水平: < 0.1 ng per μg of Wnt-3a

Stabilizer: none

Formulation: lyophilized

小鼠Wnt-3a蛋白（25ug,W3A-M-025 ）相關(guān)產(chǎn)品：

小鼠wnt-3a蛋白（WNT3A）信號(hào)通路（5ug,W3A-M-005）      

小鼠wnt-3a蛋白（WNT3A）信號(hào)通路（25ug,W3A-M-025）         

WNT-3a，小鼠wnt蛋白因子（W3A-M-100）,100ug         

WNT-5a，小鼠wnt蛋白因子（W5A-M-005）,5ug    

WNT-5a，小鼠wnt蛋白因子（W5A-M-025）,25ug          

WNT-5a，小鼠wnt蛋白因子（W5A-M-100）,100ug        

小鼠Wnt-3a蛋白（25ug,W3A-M-025 ）應(yīng)用目的：

小鼠Wnt-3a基因是Wnt基因家族中的重要成員,其編碼表達(dá)Wnt-3a信號(hào)蛋白.Wnt-3a信號(hào)蛋白可以激活經(jīng)典的Wnt/β-catenin信號(hào)通路.Wnt-3a信號(hào)蛋白對(duì)神經(jīng)干細(xì)胞表現(xiàn)出明顯的促神經(jīng)元分化的作用.我們應(yīng)用基因重組的方法,從小鼠胚腦中克隆Wnt-3a cDNA,構(gòu)建真核表達(dá)載體。

小鼠Wnt-3a蛋白（25ug,W3A-M-025 ）英文簡(jiǎn)述：

WNT-3a is a member of the WNT family of signaling proteins that play a key role in embryonic development and the integrity of adult tissues. WNT-3a is a prototypic canonical WNT that signals through the beta-catenin pathway. The predicted size of mouse WNT-3a is a monomeric protein containing 333 amino acid residues. Due to glycosylation, it migrates at an apparent molecular weight of 40 kDa by SDS-PAGE analysis under non-reducing conditions.

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