瑞禧生物-用蛋白的PEG修飾方法- NH2-PEG-SH

1.修飾反應(yīng)器設(shè)計—PEG-pellet 反應(yīng)器

創(chuàng)技術(shù)（反應(yīng)器技術(shù)和產(chǎn)物移走技術(shù)）

產(chǎn)品：

OPSS-PEG-CHO

Hydrazide-PEG-CHO

Silane-peg-CHO

Acrylates-peg-CHO

Lipoic acid-peg-CHO

Tosylate-peg-CHO

Acetylthio-peg-CHO

NPC-PEG-CHO

SAS-PEG-CHO

SC-PEG-CHO

SCM-PEG-CHO

SG-PEG-CHO

SS-PEG-CHO

SVA-PEG-CHO

Epoxides-PEG-CHO

Valeric Acids-PEG-CHO

Acrylamide-PEG-CHO

Bromide-PEG-CHO

VS-PEG-CHO

Methacrylate-PEG-CHO

Acrylates-peg-Acrylates

Lipoic acid-peg-Acrylates

Tosylate-peg-Acrylates

Aminooxy-PEG-Acrylates

NPC-PEG-Acrylates

SAS-PEG-Acrylates

SC-PEG-Acrylates

SCM-PEG-Acrylates

SG-PEG-Acrylates

SS-PEG-Acrylates

SVA-PEG-Acrylates

2.固相吸附法制備PEG修飾蛋白

產(chǎn)品包括：

NH2-PEG-SH

NH2-PEG-Biotin

NH2-PEG-OPSS

NH2-PEG-OH

NH2-PEG-Hydrazide

NH2-PEG-Silane

NH2-peg-Acrylates

NH2-peg-Lipoic acid

NH2-peg-Acetylthio

NH2-PEG-Nitrophenyl Carbonates (NPC)

NH2-PEG-Valeric Acids

NH2-PEG-Acrylamide

NH2-PEG-Bromide(Br)

NH2-PEG-Vinylsulfone(VS)

NH2-PEG-Methacrylate (MA)

NH2-PEG-Iodoacetate(IA)

NH2-PEG-Chloride

DBCO-PEG-NH2

TCO-PEG-NH2

Tetrazine-PEG-NH2

NH2-PEG-Folate

NH2-PEG-CHEMS

固相吸附法與液相吸附法的比較

產(chǎn)品包括：

Epoxides-PEG-COOH

Valeric Acids-PEG-COOH

Acrylamide-PEG-COOH

Bromide-PEG-COOH

VS-PEG-COOH

Methacrylate-PEG-COOH

IA-PEG-COOH

Chloride-PEG-COOH

DBCO-PEG-COOH

TCO-PEG-COOH

Tetrazine-PEG-COOH

Folate-PEG-COOH

CHEMS-PEG-COOH

3.PEG醛制備單修飾的用蛋白

產(chǎn)品包括：

OPSS-PEG-CHO

Hydrazide-PEG-CHO

Silane-peg-CHO

Acrylates-peg-CHO

Lipoic acid-peg-CHO

Tosylate-peg-CHO

Acetylthio-peg-CHO

NPC-PEG-CHO

SAS-PEG-CHO

SC-PEG-CHO

SCM-PEG-CHO

SG-PEG-CHO

SS-PEG-CHO

SVA-PEG-CHO

Epoxides-PEG-CHO

Valeric Acids-PEG-CHO

Acrylamide-PEG-CHO

Bromide-PEG-CHO

VS-PEG-CHO

Methacrylate-PEG-CHO

IA-PEG-CHO

Chloride-PEG-CHO

DBCO-PEG-CHO

TCO-PEG-CHO

Tetrazine-PEG-CHO

Folate-PEG-CHO

CHEMS-PEG-CHO

粒集落刺激因子 (G-CSF)

產(chǎn)品列表：

Hydrazide-PEG-OPSS

Silane-peg-OPSS

Acrylates-peg-OPSS

Lipoic acid-peg-OPSS

Tosylate-peg-OPSS

Acetylthio-peg-OPSS

Aminooxy-PEG-OPSS

NPC-PEG-OPSS

SAS-PEG-OPSS

SC-PEG-OPSS

SCM-PEG-OPSS

SG-PEG-OPSS

SS-PEG-OPSS

SVA-PEG-OPSS

Epoxides-PEG-OPSS

Valeric Acids-PEG-OPSS

Acrylamide-PEG-OPSS

Bromide-PEG-OPSS

VS-PEG-OPSS

Methacrylate-PEG-OPSS

IA-PEG-OPSS

Chloride-PEG-OPSS

DBCO-PEG-OPSS

TCO-PEG-OPSS

Tetrazine-PEG-OPSS

Folate-PEG-OPSS

CHEMS-PEG-OPSS

三批PEG30-rhG-CSF產(chǎn)品的制備

產(chǎn)品：

COOH-PEG-OH

MAL-PEG-OH

NHS-PEG-OH

N3-PEG-OH

Alkyne -PEG-OH

HS-PEG-OH

Biotin-PEG-OH

CHO-PEG-OH

OPSS-PEG-OH

Hydrazide-PEG-OH

Silane-peg-OH

Acrylates-peg-OH

Lipoic acid-peg-OH

Tosylate-peg-OH

Acetylthio-peg-OH

Aminooxy-PEG-OH

NPC-PEG-OH

SAS-PEG-OH

SC-PEG-OH

SCM-PEG-OH

SG-PEG-OH

SS-PEG-OH

SVA-PEG-OH

Epoxides-PEG-OH

Valeric Acids-PEG-OH

Acrylamide-PEG-OH

Bromide-PEG-OH

VS-PEG-OH

Methacrylate-PEG-OH

IA-PEG-OH

Chloride-PEG-OH

DBCO-PEG-OH

TCO-PEG-OH

Tetrazine-PEG-OH

Folate-PEG-OH

CHEMS-PEG-OH

修飾和劑型化產(chǎn)量水平

產(chǎn)品：

Silane-peg-Hydrazide

Acrylates-peg-Hydrazide

Lipoic acid-peg-Hydrazide

Tosylate-peg-Hydrazide

Acetylthio-peg-Hydrazide

Aminooxy-PEG-Hydrazide

NPC-PEG-Hydrazide

SAS-PEG-Hydrazide

SC-PEG-Hydrazide

SCM-PEG-Hydrazide

SG-PEG-Hydrazide

SS-PEG-Hydrazide

SVA-PEG-Hydrazide

Epoxides-PEG-Hydrazide

Valeric Acids-PEG-Hydrazide

Acrylamide-PEG-Hydrazide

Bromide-PEG-Hydrazide

VS-PEG-Hydrazide

Methacrylate-PEG-Hydrazide

IA-PEG-Hydrazide

Chloride-PEG-Hydrazide

DBCO-PEG-Hydrazide

TCO-PEG-Hydrazide

Tetrazine-PEG-Hydrazide

Folate-PEG-Hydrazide

CHEMS-PEG-Hydrazide

引入巰基的方法制備PEG修飾蛋白

產(chǎn)品列表：

Tosylate-peg-Lipoic acid

Acetylthio-peg-Lipoic acid

Aminooxy-PEG-Lipoic acid

NPC-PEG-Lipoic acid

SAS-PEG Lipoic acid

SC-PEG-Lipoic acid

SCM-PEG-Lipoic acid

SG-PEG-Lipoic acid

SS-PEG-Lipoic acid

SVA-PEG-Lipoic acid

Epoxides-PEG-Lipoic acid

Valeric Acids-PEG-Lipoic acid

Acrylamide-PEG-Lipoic acid

Bromide-PEG-Lipoic acid

VS-PEG-Lipoic acid

Methacrylate-PEG-Lipoic acid

IA-PEG-Lipoic acid

Chloride-PEG-Lipoic acid

DBCO-PEG-Lipoic acid

TCO-PEG-Lipoic acid

Tetrazine-PEG-Lipoic acid

Folate-PEG-Lipoic acid 

CHEMS-PEG-Lipoic acid