目錄:北京索萊寶科技有限公司>>抗體>>Polyclonal Antibody>> K106525PAnti-GRP78 Polyclonal Antibody
| 參考價(jià) | 面議 |
參考價(jià)：￥ 面議
供貨周期:現(xiàn)貨 規(guī)格:50ul/100ul 貨號(hào):K106525P 應(yīng)用領(lǐng)域:醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)業(yè) 主要用途:WB IHC
>更新時(shí)間：2022-08-15 05:36:40瀏覽次數(shù)：780評(píng)價(jià)
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| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 50ul/100ul |
|---|---|---|---|
| 貨號(hào) | K106525P | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)業(yè) |
| 主要用途 | WB IHC |
Anti-GRP78 Polyclonal Antibody
| 英文名稱(chēng) | Anti-GRP78 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | BIP;GRP78;HEL-S-89n;MIF2 |
| 應(yīng)用 | WB IHC |
| 稀釋比例 | WB 1:2000-5000.IHC 1:50-200. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 70kDa |
| Gene ID | 3309 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲(chǔ)存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human GRP78 |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human GRP78 |
| Subcellular Locations | Cytoplasm Endoplasmic reticulum lumen Melanosome |
| Swiss Prot | P11021 |
| 克隆類(lèi)型 | Polyclonal Antibody |
| 背景資料 | The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. |
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