CBP74224 PD1/SHP2 Reporter Cell
- 公司名稱 南京科佰生物科技有限公司
- 品牌 cobioer/科佰生物
- 型號 CBP74224
- 產地
- 廠商性質 代理商
- 更新時間 2024/12/2 16:58:55
- 訪問次數(shù) 69
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| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | T-25 Flask |
|---|---|---|---|
| 貨號 | CBP74224 | 應用領域 | 生物產業(yè) |
PD1/SHP2 Reporter Cell
| I. Background | |
腫瘤細胞可以借助免疫檢查點受體逃避機體免疫系統(tǒng)的識別和殺傷，因此阻斷免疫檢 查點受體可能是一種廣泛有效的治療方法。目前，抗 PD-1/PD-L1 抗體雖然比較 成熟，與抗 CTLA4 抗體類似，但由于存在耐藥性，患者的總體有效率較低，因此尋找新 的治療靶點迫在眉睫。 | |
| II. Background | |
PD1 SHP2 Reporter Cell 報告基因藥靶模型很好的模擬了體內 PD1/SHP2 的信號轉導過程，原理見下圖所示。
| |
| III. Introduction | |
| Expressed gene: | PD-1/SHP2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+blasticidin (5ug/ml)+hygromycin (800ug/ml) |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Representative Data | |
Figure 2. Recombinant PD1/SHP2 Reporter Cell constitutively expressing PD1.
Figure 3. Blocking of PD1 induced PD1 SHP2 Reporter Cell (C17) Activity by PD1 Neutralizing Antibody with PDL1 Target Cell (Suspension)(C4). Blocking of PDL1 induced PD1 SHP2 Reporter Cell (C17) Activity by Atezolizumab with PDL1 Target Cell (Suspension) (C4). Blocking of PD1 induced PD1 SHP2 Reporter Cell(C17) Activity by PD1 Neutralizing Antibody with PDL1 Target cell (Adherent)(C11). Blocking of PDL1 induced PD1 SHP2 Reporter Cell (C17) Activity by Atezolizumab with PDL1 Target Cell (Adherent)(C11).
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