TargetMol®半胱氨酸共價庫
We designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamide (25% and 75% of the library, respectively). These functional groups were chosen to construct the compound library because they are in the "best position" for reactivity and show selectivity in chemical proteomics screening. The cysteine covalent library contains 72 compounds.
 

TargetMol®半胱氨酸共價庫Product Description

The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. In recent years, covalent chemical probes have become an important tool for drug discovery. A large number of successful applications in the evaluation of protein druggability, especially the successful application of Cys residues, bring hope for the discovery and synthesis of new covalently modified compounds. To this end, we designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamide (25% and 75% of the library, respectively). These functional groups were chosen to construct the library because they are in the "best position" for reactivity and show selectivity in chemical proteomics screening.
 

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品牌介紹：
TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol品牌的客戶群分布于40多個國家和地區(qū)，已發(fā)展成為豐富大的化合物庫和小分子化合物研究供應(yīng)商之一。

☆ TargetMol®品牌專業(yè)提供各領(lǐng)域信號通路小分子抑制劑、拮抗劑、天然產(chǎn)物、藥物篩選化合物。
☆ 產(chǎn)品適應(yīng)在癌癥、免疫學、心血管系統(tǒng)、呼吸、神經(jīng)科學等多項科學領(lǐng)域的研發(fā)使用，超過1180萬種小分子化合物。
☆ 提供20000多個小分子抑制劑、天然產(chǎn)物和200多個化合物庫。
☆ 配備完善的化學合成和生物實驗室，可分別提供高品質(zhì)小分子抑制劑和藥物篩選技術(shù)服務(wù)。
☆ 每批產(chǎn)品都有嚴格的NMR和HPLC技術(shù)檢測，以保證產(chǎn)品高純度高質(zhì)量。