sc SC-560
- 公司名稱 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型號 sc
- 產(chǎn)地
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2019/7/11 18:12:02
- 訪問次數(shù) 604
聯(lián)系我們時請說明是化工儀器網(wǎng)上看到的信息，謝謝!
MedChemExpress (MCE) 專注于為科學家提供高品質(zhì)的生物活性小分子化合物，化合物庫及各類試劑盒，總部位于美國新澤西。
• MedChemExpress (MCE) 產(chǎn)品作用于 20 多個熱門信號通路及研究領(lǐng)域的300多個細分靶點，擁有 10000 特異性抑制劑、激動劑，以及 50 活性化合物篩選庫；
• 我們堅持對所有產(chǎn)品進行嚴格質(zhì)檢，確保產(chǎn)品的高品質(zhì)和高純度；
• MedChemExpress (MCE) 產(chǎn)品已被數(shù)萬名科學家信賴，并被大量top文獻和*引用；
• 我們擁有專業(yè)的技術(shù)團隊追蹤前沿科研進展，不斷豐富各個靶點的特異性產(chǎn)品，堅持做 “您身邊的抑制劑大師”；
• MedChemExpress (MCE) 與眾多藥企和科研機構(gòu)保持深度合作；
• 大量產(chǎn)品有中國庫存，工作日 16:00 前訂單確保當日發(fā)貨，次日送達。
MCE 中國站：www.MedChemExpress.cn
Hotline: 400-820-3792
Tel: 021-58955995
Email: sales@MedChemExpress.cn
Tech Support: 021-58950656
抑制劑，調(diào)節(jié)劑，API，天然產(chǎn)物，各種類型化合物庫
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL；5 mg；10 mg |
|---|---|---|---|
| 貨號 | HY-59105 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
SC-560
產(chǎn)品活性：SC-560是有效，選擇性的 COX-1 抑制劑，IC50 值為9 nM。
研究領(lǐng)域：Immunology/Inflammation
作用靶點：COX
In Vitro: Preincubation of COX-1 with SC-560 inhibits the conversion of arachidonic acid to PGE2 in a concentration-dependent manner. The IC50 of SC-560 for COX-2 is 6.3 μM, nearly 1,000-fold higher than with COX-1. SC-560 shows a dose and time dependent inhibitory effect on HCC cell growth. SC-560 also inhibits colony formation in soft agar and induces apoptosis in HCC cells in a dose-dependent manner. Moreover, SC-560 decreases the levels of the anti-apoptotic proteins survivin and XIAP and activates caspase 3 and 7 in a dose and time dependent fashion.
In Vivo: Oral dosing with either 10 or 30 mg/kg SC-560 1 hour before assay completely inhibits ionophore-stimulated TxB2production, indicating that SC-560 is orally bioavailable and inhibits COX-1 in vivo. SC-560 extensively distributes into rat tissues, and has a CL approaching hepatic plasma flow. The drug displays low less than 15% and formulation dependent bioavailability after oral administration and demonstrates kidney toxicity.
相關(guān)產(chǎn)品：Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Celecoxib | Acetaminophen | Indomethacin | Aspirin | Ginsenoside Rg3 | Xanthohumol | Paradol | Diclofenac | Ibuprofen | Rofecoxib | (-)-Epicatechin gallate | Flufenamic acid | Ginsenoside C-K | Meloxicam | NS-398 | Salicylic acid | Carprofen | Ketoprofen | Catechin | Gallic acid | Parecoxib Sodium | Rutaecarpine | Sulindac | Nabumetone | Naproxen | Piroxicam | Diflunisal
采購中心
化工儀器網(wǎng)